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Protomer A of WT Mpro is colored white and protomer B of WT Mpro is coloured black, nirmatrelvir in WT Mpro-nirmatrelvir intricate structure is proven as environmentally friendly sticks, protomer A with the mutant construction is coloured maritime and protomer B with the mutant composition is coloured orange, nirmatrelvir in mutant Mpro-nirmatrelv